Nutritional Insight
  • HOME
  • ABOUT
  • SERVICES
  • PUBLICATIONS
  • INSIGHTS
  • CONTACT
Featured Posts
  • New Diet and Nutrition Survey Data in the UK – Latest Insights.
  • Nutritional Insight – 2020 Roundup
  • Webinar Wisdoms
  • Choline, Neurological Development and Brain Function: A  Focus on the First 1000 Days

  • Is there Scope for a Novel Mycelium Category of Proteins alongside Animals and Plants?

  • Is there a Role for Immunonutrition in the Over 65s?

  • COVID-19 and Why the Aged Should be Swiftly reminded to take their Vitamin D.
  • Genome-Edited Foods: Are they Coming to our Supermarkets Soon?
  • Green and Blue Water Footprints: What Are They & How Do They Relate to Food?
  • Stress and Micronutrient Concentrations: Do They Impact Each Other?
  • HOME
  • ABOUT
  • SERVICES
  • PUBLICATIONS
  • INSIGHTS
  • CONTACT
Followers
Subscribe
Nutritional Insight
Nutritional Insight
  • HOME
  • ABOUT
  • SERVICES
  • PUBLICATIONS
  • INSIGHTS
  • CONTACT
  • All
  • Allergy
  • Future Directions

A Novel Treatment for Peanut Allergy: An Oral Immunotherapy in Phase III Clinical Development

  • Posted on December 5, 2018December 6, 2018
Total
0
Shares
0
0

What is Peanut Allergy?

Peanut allergy is one of the most common food allergies, and peanuts are included as an ingredient in many food stuffs. Peanuts are not actually a true nut as they grow underground, and are classified as a legume, which is the same family as peas, beans and lentils. However, the proteins in peanuts are similar in structure to nuts that grow on trees, termed tree nuts, which include cashews, almonds, walnuts, Brazil nuts, hazelnuts, pistachios, pecans and macadamia nuts. For this reason, people who are allergic to peanuts can also be allergic to tree nuts.

Unlike some food allergies an allergy to peanuts and tree nuts is lifelong in many people and can cause a severe, potentially life-threatening allergic reaction, termed anaphylaxis. Allergic reactions can be unpredictable, and only a very small amount of peanut can cause a reaction.

The number of children diagnosed with peanut allergy in the UK has more than doubled during the past two decades.

 

Oral Immunotherapy for Peanut Allergy

Peanut oral immunotherapy has previously been shown to induce desensitisation in peanut-allergic subjects, although no treatment has reached clinical development until now.

A group of clinical research scientists has teamed together to form the PALISADE Group in order to develop a novel peanut-derived oral immunotherapy drug for peanut allergy called AR101, which is currently in Phase III clinical development.

During a randomised, double-blind, placebo-controlled Phase II clinical trial, to assess safety and efficacy, AR101 demonstrated an acceptable safety profile and sufficient clinical activity as a potential immunomodulatory treatment for peanut-allergic children and young adults.

A Phase III clinical trial has recently been completed where AR101 was administered as an oral immunotherapy in children and adolescents who were highly allergic to peanut. Participants began on a 100mg dose, which was slowly built over 24 weeks to a 300mg dose. This higher dose of peanut protein was well tolerated and was ingested without dose-limiting symptoms. Furthermore, at the end of the trial, 67.2% of participants were able to ingest a 600mg challenge dose without dose-limiting symptoms. However, efficacy was not shown in participants over the age of 18.

 

The Future

AR101 is the lead investigational drug of Aimmune, a clinical-stage biopharmaceutical company developing proprietary product candidates and advancing a therapeutic approach for the treatment of peanut and other food allergies. Aimmune currently has more than 1,000 participants in clinical trials for AR101 and are continuing to advance toward providing a regulatory-approved treatment for patients with peanut allergy. AR101 could be a game changer in the protection of our children, with peanut allergy, from having a severe reaction after accidental exposure.

References:

PALISADE Group of Clinical Investigators (2018). AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med 379(21):1991-2001

Bird JA et al (2018) Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial. J Allergy Clin Immunol Pract 6(2):476-485

Total
0
Shares
Tweet 0
Share 0
Related Topics
  • Future Trends
Nutritional Insight

Previous Article
  • All
  • Brain Health
  • Omega

Omega-3 Fatty Acid Supplements: An Important Piece in the Brain Health Puzzle?

  • Posted on November 29, 2018December 6, 2018
View Post
Next Article
  • All
  • Children's Health
  • Obesity

School Lunches – Should Puddings be Off the Menu?

  • Posted on December 5, 2018December 6, 2018
View Post
You May Also Like
View Post
  • All

Webinar Wisdoms

  • Posted on September 24, 2020September 24, 2020
View Post
  • All

COVID-19 and Why the Aged Should be Swiftly reminded to take their Vitamin D.

  • Posted on March 20, 2020
View Post
  • All

Genome-Edited Foods: Are they Coming to our Supermarkets Soon?

  • Posted on February 3, 2020
View Post
  • All

Green and Blue Water Footprints: What Are They & How Do They Relate to Food?

  • Posted on November 4, 2019November 4, 2019
View Post
  • All

Stress and Micronutrient Concentrations: Do They Impact Each Other?

  • Posted on November 4, 2019November 4, 2019
View Post
  • All

Does the Nutrition Education of Physicians Need Advancing?

  • Posted on September 27, 2019September 27, 2019
View Post
  • All

Palm Oil: Should it Be Given the Same Attention as Single Use Plastics?

  • Posted on September 27, 2019September 27, 2019
View Post
  • All

Folic Acid Fortification: Assessing the Folate Status of Women After 20 Years of Fortification in the US

  • Posted on September 27, 2019September 27, 2019
Subscription Form
Keep Up to Date
Design By
SEVENTEEN
Frequently Searched
ADHD Almonds Antibiotic resistance Assessment Brexit Cardiac Health Children Choline Chrono-Nutrition Chronotype COVID-19 Depression Drug production Eggs Evidence-base Folic Acid Future of Nutrition Future Trends Growing Up Guidelines Health Health Science Information Era Microbiota micronutrients Minerals Novel methods Nutritional Profiling Nutrition and Health Claims Nutrition Exit Omega Orthorexia Polyphenols Precision Nutrition Protein Distribution Protein Quality Ratios Red Meat Registered Nutritionists Regulations Supplements Synergy Vertical Farming Vitamin D Vitamins
Nutritional Insight
  • HOME
  • ABOUT
  • SERVICES
  • PUBLICATIONS
  • INSIGHTS
  • CONTACT

Input your search keywords and press Enter.

We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies.
Cookie settingsACCEPT
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled

Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

Non-necessary

Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.